A Two-Stage Laser-Induced Mouse Model of Subretinal Fibrosis Secondary to Choroidal Neovascularization
نویسندگان
چکیده
منابع مشابه
A Mouse Model for Laser-induced Choroidal Neovascularization.
The mouse laser-induced choroidal neovascularization (CNV) model has been a crucial mainstay model for neovascular age-related macular degeneration (AMD) research. By administering targeted laser injury to the RPE and Bruch's membrane, the procedure induces angiogenesis, modeling the hallmark pathology observed in neovascular AMD. First developed in non-human primates, the laser-induced CNV mod...
متن کاملSubretinal choroidal neovascularization associated with choroidal nevus.
PURPOSE Evaluation of a large series of choroidal nevi inducing the formation of a neovascular membrane in order to more clearly define the clinical presentation and to evaluate the efficacy of various treatment options. METHOD Retrospective study of 22 clinical cases. RESULTS All nevi were situated in the posterior choroid. They had a mean diameter of 3.8 mm and a mean thickness of 1.4 mm....
متن کاملSpontaneous Resolution of Subretinal Hemorrhage Secondary to Choroidal Osteoma Unassociated with Choroidal Neovascularization
Choroidal osteoma is a rare benign intraocular tumor composed of calcification throughout the choroid. Various treatment modalities are available according to location of the tumor and the cause of the visual distortion. We report herein a 30-year-old male who was referred to our hospital with acute blurred vision as a result of the subretinal hemorrhage from choroidal osteoma. We ruled out the...
متن کاملNeuroprotectin D1 Attenuates Laser-induced Choroidal Neovascularization in Mouse
PURPOSE To examine the effects of neuroprotectin D1 (NPD1), a stereospecific derivative of docosahexaenoic acid, on choroidal neovascularization (CNV) in a laser-induced mouse model. Specifically, this was assessed by clinically grading laser-induced lesions, measuring leakage area, and volumetrically quantifying vascular endothelial cell proliferation. METHODS C57Bl/6 mice were treated with ...
متن کاملDifferent distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization
Choroidal neovascularization (CNV) is a serious complication of age‑related macular degeneration. The aim of the present study was to investigate the expression and distribution of M1 and M2 macrophages in a laser‑induced CNV adult mouse model. The mRNA expression levels of M1, M2 and pan macrophage markers, and macrophage‑associated angiogenic cytokines, were determined by reverse transcriptio...
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ژورنال
عنوان ژورنال: Translational Vision Science & Technology
سال: 2020
ISSN: 2164-2591
DOI: 10.1167/tvst.9.4.3